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| 游泳及丙酮酸钙补充对大鼠瘦素和瘦素受体水平的影响 | |
| 引用本文： | 郭英杰,王安利,丁华.游泳及丙酮酸钙补充对大鼠瘦素和瘦素受体水平的影响[J].武汉体育学院学报,2009,43(8):41. |
| 作者姓名： | 郭英杰 王安利 丁华 |
| 作者单位： | 1. 沈阳体育学院,运动医学教研室,辽宁,沈阳,110102 2. 北京体育大学,运动人体科学学院,北京,100084 |
| 摘 要： | 研究目的:以游泳大鼠为研究对象,通过检测其补充丙酮酸过程中身体成份、瘦素和瘦素受体基因表达的变化,探讨丙酮酸补充对游泳大鼠脂肪代谢的影响及机理.研究方法:选取38只健康成年雄性Wistar大鼠,随机分为安慰剂对照组、运动对照组、补充丙酮酸对照组和补充丙酮酸运动组.采用竞争放射免疫分析法测定大鼠血清瘦素和脑脊液瘦素水平;PCR法测定下丘脑瘦素受体基因表达量.研究结果:4周丙酮酸补充可明显减缓游泳大鼠体重和体脂增长速度,明显升高大鼠和游泳大鼠脑脊液瘦素水平及下丘脑瘦素受体mRNA表达水平.研究结论:丙酮酸补充可在一定程度上减慢游泳大鼠体重和体脂的增长速度,加快其能量代谢速度;并可能通过对游泳大鼠体内瘦素水平及瘦素受体基因表达量的调控,来影响游泳大鼠的脂肪代谢过程. |
| 关 键 词： | 游泳 丙酮酸补充 瘦素 瘦素受体 大鼠 |
Swimming and effects of pyruvate supplement on leptin and leptin receptor of rats |
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| GUO Ying-jie,WANG An-li,DING Hua.Swimming and effects of pyruvate supplement on leptin and leptin receptor of rats[J].Journal of Wuhan Institute of Physical Education,2009,43(8):41. | |
| Authors: | GUO Ying-jie WANG An-li DING Hua |
| Abstract: | Male swimming rat s as experimental object s were selected and t he effect s and mechanism of pyruvate supplement on lipometabolism should be discussed in an at tempt to measure some changes regarding body composition and leptin and leptin receptor . 38 male Wistar rat s were selected and ran2 domly divided into four group s , placebo cont rol group , t raining cont rol group , supplement cont rol group , t raining and supplement group . The serum and cerebrospinal fluid leptin were determined by Radioimmunoassay Met hod , leptin recptor (OB2R) mRNA in hypot halamus by PCR met hod. It was seen t hat four weeks’supplement of pyruvate could weaken weight and body fat gaining remarkably in swimming rat s and increase cerebrospinal fluid leptin and leptin receptor level in hypot halamus in rat s and swimming rat s dramatically. The supplement of pyruvate could weaken weight and body fat gai2 ning remarkably , which could accelerate t he speed of t he body energy metabolism. It indicated t hat pyruvate supplement could regulate lipometabolism in swimming rat s by means of the effect on leptin and leptin receptor level s. |
| Keywords: | swimming pyruvate supplement leptin leptin receptor rat |
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