Hepatoprotective effect of<Emphasis Type="Italic">Hygrophila spinosa</Emphasis> and<Emphasis Type="Italic">Cassia occidentalis</Emphasis> on carbon tetrachloride induced liver damage in experimental rats |
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| Authors: | K Usha G Mary Kasturi P Hemalatha |
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| Institution: | (1) Department of Biochemistry, Avinashilingam University, 641 043 Coimbatore |
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| Abstract: | The present study was undertaken to analyze the levels of some known antioxidant (both enzymic and non enzymic) activities
in the rootsof Hygrophila spinosa andCassia occidentalis also to find out the hepatoprotective effect of the same in carbon tetrachloride induced liver damage in albino rats. The
roots were found to be rich in antioxidants. Liver damage in rats were induced by carbon tetrachloride. To find out the hepatoprotective
activity, the aqueous extract of the plant root samples were administrated to rats for 15 days. The serum marker enzymes Aspartate
transaminase, Alanine transaminase and Gama Glutamyl were measured in experimental animals. The increased enzyme levels after
liver damage with carbon tetrachloride were nearing to normal value when treated with aqueous extract of the root samples.
Histopathological observation also proved the hepatoprotectivity of the root samples. |
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| Keywords: | Hepatoprotective effect Antioxidants Liver damage Liver marker enzymes |
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