Archaeosome: As New Drug Carrier for Delivery of Paclitaxel to Breast Cancer |
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| Authors: | Seyed Ebrahim Alavi Hamidreza Mansouri Maedeh Koohi Moftakhari Esfahani Fatemeh Movahedi Azim Akbarzadeh Mohsen Chiani |
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| Institution: | 1. Department of Chemical Engineering, Lamerd Branch, Islamic Azad University, Lamerd, Iran
2. Pilot Biotechnology Department, Pasteur Institute of Iran, No 358, 12 Farvardin Street, Jomhoori Avenue, 13169-43551, Tehran, Iran
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| Abstract: | In the present study, paclitaxel was archaeosomed to reduce side effects and improve its therapeutic index. Carriers have made a big evolution in treatment of many diseases in recent years. Lipid carriers are of special importance among carriers. Archaeosome is one of the lipid carriers. Paclitaxel is one of the drugs used to treat breast cancer which has some unwanted side effects despite its therapeutic effects. Archaeosomes were extracted from methanogenic archi bacteria and synthesized with a certain ratio of paclitaxel in PBS. The mean diameter of archaeosomal paclitaxel was measured by Zeta sizer instrument, Drug releasing of archaeosomal paclitaxel was examined within 26 h which results showed that the most drug releasing occurs during first 3 h. The cytotoxicity effect of archaeosomal paclitaxel on breast cancer’s cell line was evaluated by MTT assay which results showed that the cytotoxicity effect of archaeosomal paclitaxel on breast cancer’s cell line is more than that of the standard paclitaxel formulation. The results indicated that new drug delivery of paclitaxel using archaeosome, increases the therapeutic index of the drug. |
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| Keywords: | Paclitaxel Archaeosome Drug delivery Breast cancer |
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