Acrosin activity in spermatozoa of infertile Nigerian males |
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| Authors: | M A Emokpae P O Uadia |
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| Institution: | (1) Department of Chemical Pathology, Aminu Kano Teaching Hospital, Kano;(2) Department of Biochemistry, University of Benin, Benin City |
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| Abstract: | The objective of this study was to evaluate acrosin activity in spermatozoa of infertile Nigerian men and to compare with
those of the fertile men. The acrosin activity was evaluated using the Acroscreen reagent kit. The acrosin activity of the
fertile men was 40.7±5.2 mIU/106 sperm (range 30.1–51.3) and those of the infertile men was 22.4±8.33 mIU/106 sperm (range 5.7–39.1). The difference in the mean was statistically significant (P<0.001). There was a subpopulation of
the infertile men who had their acrosin activity within normal range of the fertile men, 32.9±1.57 mIU/106 sperm. But the difference in the mean was statistically significant (P<0.001). Acrosin activity decreased with increased
morphological changes in the spermatozoa. It is concluded that acrosin activity in the infertile Nigerian men is significantly
lower than that in the fertile men. Acrosin activity may also be affected by morphological changes in the spermatozoa. |
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| Keywords: | Acrosin activity spermatozoa male infertility |
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