| 氯化锌催化三取代基咪唑的合成 |
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| 引用本文： | 任一鸣,张旭,杨仁春.氯化锌催化三取代基咪唑的合成[J].巢湖学院学报,2011(6):104-107. |
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| 作者姓名： | 任一鸣 张旭 杨仁春 |
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| 作者单位： | 安徽工程大学生物与化学工程学院,安徽芜湖,241000 |
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| 基金项目： | 安徽工程大学引进人才科研启动基金 |
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| 摘 要： | 以乙醇为溶剂,苯偶酰,苯甲醛衍生物和醋酸铵在氯化锌的催化下一步合成了三取代基咪唑.考察了氯化锌的用量以及温度对反应产率的影响,根据实验结果确定了较佳的反应条件,即n(苯偶酰):n(苯甲醛):n(醋酸铵):n(ZnCl2)=1.0:1.0:2.5:0.2,反应温度78°C,反应时间3h.在较佳的反应条件下2,4,5-三苯基咪唑的产率可达到86%.该方法反应条件温和、方便实用、操作简单.本文探讨了可能的反应机理.
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| 关 键 词： | 氯化锌 三取代基咪唑 苯偶酰 |
ZINC CHLORIDE CATALYZED SYNTHESIS OF 2,4,5-TRISUBSTITUTED IMIDAZOLES |
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| REN Yi-ming ZHANG Xu YANG Ren-chun.ZINC CHLORIDE CATALYZED SYNTHESIS OF 2,4,5-TRISUBSTITUTED IMIDAZOLES[J].Chaohu College Journal,2011(6):104-107. |
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| Authors: | REN Yi-ming ZHANG Xu YANG Ren-chun |
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| Institution: | REN Yi-ming ZHANG Xu YANG Ren-chun(Department of Biochemical Engineering,Anhui Polytechnic University,Wuhu Anhui 241000) |
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| Abstract: | Direct one-pot synthesis of various 2,4,5-trisubstituted imidazoles from benzil, aldehydes and ammonium acetate us- ing zinc chloride as the catalyst in EtOH is described with good product yields. The influences of reaction conditions such as ratio of zinc chloride, temperature were described. The yield of 2,4,5-triphenylimidazole is 86% under the optimized reaction conditions were that 78℃, n（benzil）：n（benzaldehyde）：n（NI-14OAe）：n（ZnC12）=1.0：1.0：2.5： 0.2, and 3h. This method is relatively simple and mild. Such method will contribute to the sysnthesis of 2,4,5-trisubstituted imidazoles to some extent. In this paper, a possible reaction mechanism is proposed. |
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| Keywords: | zinc chloride 2 4 5-trisubstituted imidazoles benzyl |
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