| 运动干预改善慢性肾病的研究进展 |
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| 引用本文： | 段永昌,姜娜.运动干预改善慢性肾病的研究进展[J].福建体育科技,2013(6):39-41. |
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| 作者姓名： | 段永昌 姜娜 |
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| 作者单位： | 陕西师范大学体育学院,陕西西安710062 |
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| 摘 要： | 慢性肾脏疾病是复杂的威胁公共健康的疾病。慢性肾病与高致死率、高发病率、高治疗费用相关。肾脏纤维化是肾脏慢性病变的病理形态表现，是指在各种致病因子如炎性因子，机械性损伤，药物等导致的细胞外基质（extracellarmatrix。ECM）合成增多降解减少，肾小球基底膜增厚，最终影响肾脏功能。目前关于慢性肾病的研究重要集中在药物筛选方面，而运动是否能改善慢性肾脏疾病的研究较少。本文通过文献资料法与逻辑推理相结合的方法总结运动与慢性肾脏疾病的研究，总结指出：1适当的运动通过减弱肾脏病变引起的纤维化程度，改善慢性肾脏疾病。2运动可以通过调解TGF-β1／Smad信号通路改善慢性肾脏疾病
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| 关 键 词： | 慢性肾脏疾病 纤维化 运动 综述 |
The review of the Exercise Intervention improve the Chronic Kidney Disease |
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| Duan Yong- chang,JIANG Na.The review of the Exercise Intervention improve the Chronic Kidney Disease[J].Fujian Sports Science and Technology,2013(6):39-41. |
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| Authors: | Duan Yong- chang JIANG Na |
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| Institution: | ( PE. institue of Shannxi Normal University, Xi＇ an 710062, Shan＇ xi China) |
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| Abstract: | Chronic kidney disease is a complexly disease that threaten the public healthy, chronic kidney disease is correlate with morbidity, mortality and more cost. renal interstitial fibrosis is the result by the inflammatory re- sponse , stress stimulus lesion and pharmaceuticals stimulus that lead to the deposition and glomerular basement membrane proliferation in the extra cell matrix and influence the renal function finally. Renal interstitial fibrosis treat as the common approach of pathomorphology, so current research aggregate in the drug screening and the ex- ercise intervention is less. This review is base on the current study and summarize that （ 1 ） appropriate exercise improve the chronic kidney disease through ameliorate the renal fibrosis , （2） exercise through influence TGF - 81/Smad sianal pathway attenuate CKD. |
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| Keywords: | Chronic Kidney Disease Fibrosis Exercise Review |
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