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| 运动对高胆固醇饮食小鼠主动脉脂质沉积影响的透射电 镜观察 | |
| 引用本文： | 李瑞,刘善云,陈家琦.运动对高胆固醇饮食小鼠主动脉脂质沉积影响的透射电 镜观察[J].天津体育学院学报,2002,17(3):8-10. |
| 作者姓名： | 李瑞 刘善云 陈家琦 |
| 作者单位： | 1. 天津体育学院体育系 2. 天津体育学院社会体育与管理系 3. 天津体育学院运动医学研究所,天津300381 |
| 摘 要： | 目的：建立高胆固醇饮食诱导动脉粥样硬化（AS）小鼠模型，透射电镜观察有氧运动对高胆固醇饮食小鼠主动脉壁的影响。方法：C57BL/6J(C57B6)小鼠19只，随机分为高胆固醇饮食对照组（n=10）和高胆固醇饮食运动组（n=9），实验为期12周。取主动脉以醋酸铀及柠檬酸盐染色，进行透射电镜观察。结果：高胆固醇饮食对照组小鼠主动脉内皮及中膜平滑肌损伤严重，而运动组病变轻微。结论：运动可减少或防止高胆固醇饮食小鼠主动脉高血凝状态，并能明显地减少胆固醇的沉着及其相关病损。 |
| 关 键 词： | 动脉粥样硬化 高胆固醇饮食 有氧运动 主动脉壁 鼠 透射电镜 主动脉脂质沉积 |
| 文章编号： | 1005-0000(2002)03-0008-03 |
Observation of Transmission Electron Microscope On Effect of Exercise on Aortic Lipid Sediment of Mice Fed with Hyper-cholesterol Diet |
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| LI Rui,LIU Shan-yun and CHEN Jia-qi.Observation of Transmission Electron Microscope On Effect of Exercise on Aortic Lipid Sediment of Mice Fed with Hyper-cholesterol Diet[J].Journal of Tianjin Institute of Physical Education,2002,17(3):8-10. | |
| Authors: | LI Rui LIU Shan-yun and CHEN Jia-qi |
| Institution: | LI Rui 1,LIU Shan yun 2,CHEN Jia qi 3 |
| Abstract: | Aims: The atherosclerosis (AS) model of mice was set up induced with hyper cholesterol diet. Transmission electron microscopic was used to observe the effect of aerobic exercise on the mice aorta with hyper cholesterol diet. Methods:Nineteen C57B6 mice were divided into control group (n=10) with hyper cholesterol diet and the group of hyper cholesterol diet plus exercise (n=9). After 12 weeks of the experiment, the aortas were stained with uranium acetate and citrate, observed with electron microscopic. Results:The endothelium and smooth muscle of aorta of group of hyper cholesterol diet were damaged severely,while the aorta of control group were only damaged slightly. Conclusions:The present observation showed that aerobic exercise could decrease or prevent hyper thrombinemia and significantly decrease cholesterol sediment and pathological damage. |
| Keywords: | AS hyper cholesterol diet aerobic exercise arterial wall |
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