| 运动对胰岛素受体及相关信号传导蛋白的影响 |
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| 引用本文： | 孙清涛,许豪文.运动对胰岛素受体及相关信号传导蛋白的影响[J].体育与科学,2002,23(2):66-68. |
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| 作者姓名： | 孙清涛 许豪文 |
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| 作者单位： | 华东师范大学体育与健康学院,上海,200062 |
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| 摘 要： | 运动训练已经在预防和治疗胰岛素抵抗和2型糖尿病方面得到成功的应用。经常参加运动训练的人骨骼肌胰岛素敏感性提高，运动会引起胰岛素受体(IR)、受体底物(IRS-1等)及受体后各相关信号传导蛋白(ERK1／2，P13-激酶，GLUT4等)发生相应的变化。然而，目前对运动训练可以提高胰岛素介导的信号传导机制尚未完全明了。
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| 关 键 词： | 运动训练 胰岛素受体 胰岛素受体底物 信号传导 |
| 文章编号： | 1004-4590(2002)02-0066-03 |
| 修稿时间： | 2002年1月20日 |
Effects of Exercise on Insulin Receptors and Proteins involved in Signal Transduction |
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| Abstract: | Exercise has long been used to successfully treat and prevent insulin resistance and Type 2 diabetes. A number of investigators have shown increased skeletal muscle insulin sensitivity among people who exercise on a regular basis. Mechanisms that have been proposed to account for these exercise-related improvements include increased insulin receptors ,insulin receptor substrate-1 and proteins involved in signal transduction (ERK1/2, PI3-K, GLUT-4, et.al).Nevertheless, our knowledge of the mechanisms that explain how exercise training improves insulin mediated signal transduction remains unclear. |
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| Keywords: | exercise insulin receptors insulin receptor substarte 1 signal transduction |
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