Role of bilirubin, vitamin C and ceruloplasmin as antioxidants in coronary artery disease [CAD] |
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| Authors: | V K Verma V Ramesh Satyendra Tewari R K Gupta Nakul Sinha C M Pandey |
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| Institution: | (1) Department of Pathology, Cardiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences [SGPGIMS], Raebareli Road, 226 014 Lucknow;(2) Department of Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences [SGPGIMS], Raebareli Road, 226 014 Lucknow;(3) Clinical Chemistry, Pathology Department, SGP GIMS, Rae Bareli Road, 226 014 Lucknow |
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| Abstract: | A study has been carried out on 250 CAD patients to see how the serum levels of three antioxidants i.e., Vitamin C, Bilirubin
and Ceruloplasmin are related to the CAD risk factors and characteristics in these patients. The number of severe category
CAD patients declined by 7–18% with increasing serum levels of the three antioxidants and, triple vessel disease declined
by 14–20%. A decline of 39% in Myocardial Infarction (MI) occurred with increasing serum Ceruloplasmin. Serum Ceruloplasmin
was significantly lower in the MI group compared to the non MI group CAD patients. There was a steady and a significant decline
in the mean values of serum levels of cholesterol, Triglyceride, VLDL cholesterol along with BMI with increasing serum level.
The study indicates that with increasing serum levels of the three antioxidants studied, the % MI along with % Triple vessel
disease and severity of CAD goes down suggesting that the modifiable risk factors have to be suitably modified in order to
maintain a reasonably high level of these antioxidants, as the risk factors are inversely related to the serum antioxidant
levels. |
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| Keywords: | Antioxidants Bilirubin Ceruloplasmin CAD Role Serum Levels Vitamin C |
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