Effects of interaction of vitamin A and <Emphasis Type="Italic">Rauwolfia vomitoria</Emphasis> root bark extract on marker enzymes of cardiac diseases |
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| Authors: | M I Akpanabiatu I B Umoh E E Edet T Ekanem S Ukaffia J I Ndem |
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| Institution: | (1) Cardiovascular Department, First Clinical College of Harbin Medical University, 23 Youzheng Street, Harbin, 150001, People’s Republic of China;(2) Department of Cardiology, Yangzhou Hongquan Hospital, Yangzhou, 225200, People’s Republic of China;(3) Department of Cardiology, Shanghai Jiaotong University Affiliated First people’s Hospital, 85 Wujin Road, Shanghai, 200080, People’s Republic of China;(4) Department of Immunology, Harbin Medical University, Harbin, 150081, China;(5) International Medical Care Department, First Clinical College of Harbin Medical University, Harbin, 150001, People’s Republic of China; |
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| Abstract: | Serum creatine kinase (CK), creatine kinase isoenzyme (CK-MB) and aspartate aminotransferase (AST) are key players in the
diagnostic study of cardiac complications. These enzymes are specific diagnostic markers of myocardial infarction and hypertension
is a disease condition characterized with a wide range of complications, including myocardial infarction. In this study, we
determined the effects of interaction of vitamin A and Rauwolfia vomitoria (RV) root bark extract on marker enzymes of cardiac
diseases. CK and CK-MB activities had significant decrease in the group of animals with concomitant administration of vitamin
A (40 IU/kg body wt.) and 150 mg/kg body wt. of RV root bark extract. At the interaction of vitamin A with 300 mg/kg body
wt. RV root bark extract, CK-MB only showed significant (p ≥ 0.05) decrease while CK decreased insignificantly. Also at the
interaction of vitamin A with 300 mg/kg body wt. RV root bark extract, AST increased significantly but decreased significantly
at the interaction of vitamin A (40 IU/kg body wt.) and 150 mg/kg body wt. of RV root bark extract. Our findings showed that
vitamin A dose did not lower the activities of cardiac marker enzymes. However, concomitant administration of RV root bark
extract at 150 mg/kg body wt. with vitamin A shows significant reduction in the activities of CK, CK-MB and AST. These findings
suggest that interaction of vitamin A with RV root bark extract would be a meaningful ethno-pharmaceutical approach in the
management of myocardial infarction and treatment of hypertension. |
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