Chemistry is a subject which involves a number of abstract concepts, making it a difficult and frustrating learning process for many students. Educators and researchers believe that technology could provide an opportunity to address this problem. However, it is challenging to find a model for appropriately and successfully integrating technology into chemistry education. Therefore, in this study, a review was conducted on the technology-enhanced chemistry learning studies published in Social Science Citation Index (SSCI) journals from 2010 to 2019. This study searched the target articles from the Web of Science (WOS) database and excluded those studies that did not adopt a comparative research design. Finally, 60 studies were included in this research trend analysis. A coding scheme was developed for the types of technology, the types of learning tools, the roles of technology in chemistry learning, learning topics, learning environments, participants, research designs, and the learning outcomes the researchers evaluated. From the analysis results, it was found that (1) inorganic chemistry and physical chemistry courses were the main learning topics, while the formal classroom was most often referred to as the research setting. The most frequently discussed issue was students’ learning achievement. (2) Regarding technology integration, offering students learning content through personal computers was the main activity mode. The technology was used for lower-level implementation, that is, providing supplementary materials for students. (3) Finally, using keyword analysis, it is possible to extract the recent concerns of the researchers, and from the results of the study, it is clear that the researchers are placing increasing emphasis on learners’ experience and skill development in the learning process. Accordingly, this study highlights the features of the research trends and then provides suggestions for researchers in the technology-enhanced chemistry learning field.