Antioxidant Effect of Caffeic Acid on Oxytetracycline Induced Lipid Peroxidation in Albino Rats |
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| Authors: | R Jayanthi P Subash |
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| Institution: | (1) Department of Biochemistry, Faculty of Science, Mahatma Gandhi Medical College & Research Institute, Pondy–Cuddalore Main Road, Pillaiyarkuppam, Pondicherry, 607 402, India;(2) Department of Biochemistry, Faculty of Medicine, Mahatma Gandhi Medical College & Research Institute, Pondy–Cuddalore Main Road, Pillaiyarkuppam, Pondicherry, 607 402, India |
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| Abstract: | Caffeic acid is a well-known phenolic compound widely present in plant kingdom. The aim of this study was to investigate the
possible protective effect of caffeic acid (CA) against oxytetracycline (OXT) induced hepatotoxicity in male Albino Wistar
rats. A total of 30 rats weighing 150–170 g were randomly divided into five groups of six rats in each group. Oral administration
of OXT (200 mg/kg body weight/day) for 15 days produced hepatic damage as manifested by a significant increase in serum hepatic
markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase
(LDH), bilirubin and increased plasma and hepatic lipid peroxidation indices (TBARS and hydroperoxide). The present finding
shows that the levels of enzymatic antioxidants namely superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase
(GPx) were significantly decreased in OXT intoxicated rats. Upon oral administration of caffeic acid (40 mg/kg body weight/day)
there were decreased hepatic marker activities, bilirubin and lipid peroxidation and increased enzymatic antioxidants in OXT + Caffeic
acid group compared to Normal + OXT group(P < 0.05). Our study suggests that caffeic acid has antioxidant property and hepatoprotective ability against OXT induced toxicity. |
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| Keywords: | Caffeic acid Oxytetracycline Hepatoprotective and Lipid peroxidation |
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