DNA methylation in the tumor microenvironment |
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| Authors: | Meng-wen Zhang Xu Che Shu Zheng Lei Zheng |
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| Institution: | 1.The Second Affiliated Hospital, School of Medicine,Zhejiang University,Hangzhou,China;2.The Key Laboratory of Cancer Prevention and Intervention,China National Ministry of Education,Hangzhou,China;3.Department of Oncology,Johns Hopkins University School of Medicine,Baltimore,USA;4.The Sidney Kimmel Cancer Center,Johns Hopkins University School of Medicine,Baltimore,USA |
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| Abstract: | The tumor microenvironment (TME) plays an important role in supporting cancer progression. The TME is composed of tumor cells, the surrounding tumor-associated stromal cells, and the extracellular matrix (ECM). Crosstalk between the TME components contributes to tumorigenesis. Recently, one of our studies showed that pancreatic ductal adenocarcinoma (PDAC) cells can induce DNA methylation in cancer-associated fibroblasts (CAFs), thereby modifying tumor-stromal interactions in the TME, and subsequently creating a TME that supports tumor growth. Here we summarize recent studies about how DNA methylation affects tumorigenesis through regulating tumorassociated stromal components including fibroblasts and immune cells. We also discuss the potential for targeting DNA methylation for the treatment of cancers. |
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