| Hepcidin：低氧训练对机体铁代谢影响的关键调节因子 |
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| 作者姓名： | 杨杰 ;李海洲 |
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| 作者单位： | [1]中国人民武装警察部队学院,河北廊坊065000; [2]廊坊师范学院,河北廊坊065000 |
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| 摘 要： | 机体稳定的铁状态是维持生命活动的基本要素.诸多因素影响机体铁代谢,包括：饮食、低氧、运动等,其中低氧对机体铁代谢的影响备受关注.在机体铁代谢这个严密的调节系统中,关键调节因子Hepcidin在低氧影响机体铁稳态中起到了桥梁作用.低氧状态下Hepcidin调节铁代谢的分子机制成为近年来研究的热点.研究发现,低氧诱导因子（hypoxia inducible factor,HIF）/低氧反应元件（hypoxia response element,HRE）系统发挥着重要的作用,同时发现肥胖引起的局部低氧会导致铁代谢的紊乱,与低氧引发的炎症导致Hepcidin水平异常有关.另外发现低氧训练引起机体内氧浓度的变化会通过Hepcidin引起机体铁代谢适应性交化.
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| 关 键 词： | Hepcidin 低氧 铁 肥胖 低氧训练 |
Hepcidin is a Key Regulator of Iron Metabolism during Hypoxia Training |
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| Institution: | YANG Jie, LI Hai-zhou |
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| Abstract: | Iron status is the basic element to maintain the stability of life activities. Many factors affect iron me- tabolism, including： diet, hypoxia, exercise and so on, among which Hypoxia effect on body iron metabolism is highly fo- cused. The state of hypoxia occurs under physiological adaptive changes, including increased erythropoietin, iron absorp- tion and utilization increase and so on. in the strict regulation iron metabolism system of human body, Hepcidin is a key regulator of iron metabolism in hypoxic affecting iron metabolism and playing a role as a bridge. Hepcidin＇ molecular mechanisms that regulates iron metabolism under hypoxia condition has become one of the research hotspots in recent years. Researches has uncovered that HIF/HRE system plays an important role, and obesity caused by local hypoxia leads to iron metabolic disorders, which is related to inflammations caused by hypoxia that makes Hepcidin level unusual. What＇s more, the pathway of efficient of hypoxia training on iron metabolism will be the focus of future research. |
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| Keywords: | Hepcidin hypoxia iron obesity Hypoxia training |
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