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| 啤酒酵母阻断白色念珠菌感染的实验研究 | |
| 引用本文： | 刘为国,刘超,李维佳,高爽,秦美霞,王爽.啤酒酵母阻断白色念珠菌感染的实验研究[J].大连大学学报,2006,27(2):84-87. |
| 作者姓名： | 刘为国 刘超 李维佳 高爽 秦美霞 王爽 |
| 作者单位： | 1. 大连大学,医学院,辽宁,大连,116622 2. 丹东市第一医院,辽宁,丹东,118000 3. 瓦房店市中医院,辽宁,瓦房店,116000 |
| 基金项目： | 大连市科技基金项目,(2004B3SF15) |
| 摘 要： | 目的:探讨啤酒酵母菌对白色念珠菌感染的影响作用及机制.方法:用啤酒酵母免疫家兔后,经家兔耳的皮下注射白色念珠菌,建立播散性念珠菌病动物感染模型,观察啤酒酵母菌免疫组和对照组家兔的感染状况;通过测定抗体效价和巨噬细胞吞噬功能,了解啤酒酵母的免疫效果.结果:观察显示:①免疫组兔耳皮下注射区红肿面积明显小于对照组;②肾脏充血及肿胀程度免疫组小于对照组,同时,对照组肾脏出现肉眼可见的脓肿灶;③病理诊断显示,免疫组炎性细胞浸润范围小;④免疫组抗体效价明显高于对照组,吞噬百分率与吞噬指数,免疫组与对照组有明显差异(P<0.01).结论:啤酒酵母能够提高机体免疫功能,减轻白色念珠菌的局部感染及全身感染. |
| 关 键 词： | 啤酒酵母菌 白色念珠菌 感染 |
| 文章编号： | 1008-2395（2006）02-0084-04 |
| 收稿时间： | 2005-12-10 |
| 修稿时间： | 2005年12月10 |
Experimental study of inhibiting candida albicans infection by saccharomyces cerevisiae |
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| LIU Wei-guo,LIU Chao,LI Wei-jia,WANG Shuang,GAO Shuang,QIN Mei-xia.Experimental study of inhibiting candida albicans infection by saccharomyces cerevisiae[J].Journal of Dalian University,2006,27(2):84-87. | |
| Authors: | LIU Wei-guo LIU Chao LI Wei-jia WANG Shuang GAO Shuang QIN Mei-xia |
| Abstract: | Objective] The experiment is aim to study the inhibiting effect of Saccharomyces cerevisiae to Candida albicans infection.Methods] Ear skin of rabbits was injected by living Candida albicans,which was used to utlize the animal's infection model of disseminated meuritis.The condition of the rabbits immunized by Saccharomyces cerevisiae and those in control group was observed.Determining the antibody titres and the phagocytic function of macrophage were used to understand the immune effects of Saccharomyces cerevisiae.Results] ①The flare area of injection site in immune group is smaller than that in control group.②The targescence and hyperemia in kidney in the immune group are slight,meanwhile,the abscessus in kidney are visible in control group.③The pathologic diagnosis indicates the infiltration range of inflammatory cell of immune group is smaller than that of control group.④The antibody titres in immune group are significantly higher than that in control group,and there is a statistical significance in the ability of phagocytosis of the macrophage between the control group and immune group(P<0.01).Conclusion] Saccharomyces cerevisiae can lighten local infection and systemic infection.It can also improve the immunologic function and induce to produce obstructive effect against Candida species. |
| Keywords: | saccharomyces cerevisiae candida albicans infection |
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