Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever |
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| Authors: | Yildirim Kadir Uzkeser Hulya Keles Mustafa Karatay Saliha Kiziltunc Ahmet Kaya Muhammet Dursun Yildirim Abdulkadir |
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| Institution: | Department of Physical Medicine and Rehabilitation, Ataturk University, Medical Faculty, Erzurum, Turkey. |
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| Abstract: | Introduction:The aim of this study was to investigate whether serum levels of interleukin-1β (IL–1β) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period.Materials and methods:The serum levels of IL-1β, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fibrinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers.Results:Serum IL-1β levels were significantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically significant difference in the serum levels of ESR, CRP and fibrinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a significant correlation between IL-1β and CRP (r = 0.513, P = 0.002) values of FMF group.Conclusions:In conclusion, our results confirm the presence of increased IL-1β levels in FMF patients during attack-free period. Serum IL-1β values seems to correlate with CRP levels. The elevation of IL-1β levels may be important in monitoring subclinical inflammation of attack free period in FMF patients. |
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| Keywords: | familial Mediterranean fever cytokine IL-1β inflammation |
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