Antihyperglycemic and antilipidperoxidative effects of<Emphasis Type="Italic">Tephrosia purpurea</Emphasis> seed extract in streptozotocin induced diabetic rats |
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| Authors: | P Pavana S Sethupathy S Manoharan |
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| Institution: | (1) Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamilnadu;(2) Dept of Biochemistry, Faculty of Science, Annamalai University, 608002 Annamalai Nagar, Tamilnadu, India |
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| Abstract: | The aim of the present study was to evaluate the antihyperglycemic and antilipidperoxidative effects of ethanolic seed extract
ofTephrosia purpurea (TpEt) in streptozotocin induced diabetic rats. Hyperglycemia associated with an altered hexokinase and glucose 6 phosphatase
activities, elevated lipid peroxidation, disturbed enzymatic and non-enzymatic antioxidants status were observed in streptozotocin
induced diabetic rats. Oral administration of “TpEt” at a dose of 300mg/kg bw showed significant antihyperglcemic and antilipidperoxidative
effects as well as increased the activities of enzymatic antioxidants and levels of non enzymatic antioxidants. We also noticed
that the antihyperglycemic effect of plant drug (TpEt) was comparable to that of the reference drug glibenclamide. Our results
clearly indicate that “TpEt” has potent antihyperglycemic and antilipidperoxidative effects in streptozotocin induced diabetic
rats and therefore further studies are warranted to isolate and characterize the bioactive antidiabetic principles from “TpEt”. |
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| Keywords: | Streptozotocin Tephrosia purpurea Antioxidants Lipid peroxidation |
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