Parathyroid and Calcium Status in Patients with Thalassemia |
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| Authors: | Meenu Goyal Pankaj Abrol Harbans Lal |
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| Institution: | (1) Department of Pediatrics, Post Graduate Institute of Medical sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India;(2) Department of Biochemistry, Post Graduate Institute of Medical sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India;(3) Present address: Department of Biochemistry, Maharaja Agrasen Medical College, Agroha (Hissar), Haryana, India; |
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| Abstract: | Thirty patients with thalassemia major receiving repeated blood transfusion were studied to see their serum parathyroid hormone
(PTH) and calcium status. Serum PTH, serum and 24 h urinary calcium, and serum alkaline phosphatase, phosphorus, and albumin-corrected
calcium levels were determined. Half of these patients, in addition to transfusion, were also supplemented with vitamin D
(60,000 IU for 10d) and calcium (1500 mg/day for 3 months). Serum PTH, and serum and 24 h urinary calcium concentrations of
the patients receiving transfusions were found to be significantly reduced while their serum alkaline phosphatase, phosphorus,
and albumin-corrected calcium levels were not significantly altered when compared to the respective mean values for the control
group. Vitamin D and calcium supplementation significantly increased their serum PTH and calcium levels. Supplementations
also increased urinary excretion of calcium. The results thus suggest that patients with thalassemia have hypoparathyroidism
and reduced serum calcium concentrations that in turn were improved with vitamin D and calcium supplementation. |
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| Keywords: | Parathyroid hormone Calcium Thalassemia |
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