| 手性胍的不对称催化反应研究进展 |
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| 引用本文： | 杨继远,徐世林.手性胍的不对称催化反应研究进展[J].商丘职业技术学院学报,2008,7(5):97-99. |
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| 作者姓名： | 杨继远 徐世林 |
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| 作者单位： | 商丘职业技术学院,河南,商丘,476000 |
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| 摘 要： | 目前，不对称催化反应是获取单一异构体手性化合物的最有前景的方法，它仅用少量手性催化剂就可以获取特定构型的手性化合物．而采用适当的手性源是获取单一异构体的手性化合物的另一种重要的方法．研究发现了多种新的含有胍基并具有很强的生理活性的天然产物，由于胍基化合物具有这些药理活性和分子识别的特性，对胍基化合物的合成就显得非常重要．基于胍可催化反应类型的多样性和反应的易操作性，诸如Michael加成反应、Strecker反应和Henry反应等，近年来胍催化反应成为了有机反应方法学研究的一个重要领域．手性胍催化的一些不对称反应的成功，更显示了手性胍在不对称反应中的巨大潜力．
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| 关 键 词： | 手性胍 不对称Henry反应 不对称Strecker反应 不对称Michael/Aldoljia加成反应 不对称Aldol反应 |
Asymmetric Catalyzing Reaction Studying Progressing of Chiral Guanidine |
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| YANG Ji-yuan,XU Shi-lin.Asymmetric Catalyzing Reaction Studying Progressing of Chiral Guanidine[J].Journal of Shangqiu Vocational and Technical College,2008,7(5):97-99. |
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| Authors: | YANG Ji-yuan XU Shi-lin |
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| Institution: | YANG Ji - yuan, XU Shi - lin ( Shangqiu Vocational ＆ Technical College,Shangqiu 476100, China) |
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| Abstract: | In recent years, asymmetric catalyzes reaction is the most prospect method to gain unitary isomer chiral compound, it can gain specially appointed configuration chiral compound with a few chiral catalyzer. Another method to gain unitary isomer chiral compound is to use appropriate chiral source. The research found a lot of nature products which have guanidine groups and very strong physiology activity, it has very important right to combine guanidine group compound because of the pharmacology activity and the characteristic property of molecule distinguish. Based on diversity and easy operatability of guanidine may catalyze reaction such as Michael addition reaction, Strecker reaction and Henry reaction ect, the guanidine catalyzes reaction has become an important field that organic reaction method mimics studying in recent years. A few reactive asymmetric successes that the chiral guanidine catalyzes, the enormous potential of chiral guanidine has been demonstrated in asymmetric reaction. |
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| Keywords: | chiral guanidine asymmetric Henry reaction asymmetric Strecker reaction asymmetric Michael/Aldol addition reaction Diastereoselective Aldol reaction |
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