Impaired hypothalamic-pituitary-gonadal axis function in men with diabetes mellitus |
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| Authors: | M Maneesh H Jayalakshmi T A Singh Amit Chakrabarti |
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| Institution: | (1) Department of Biochemistry, Melaka Manipal Medical College, Manipal, Karnataka;(2) Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim;(3) Department of Pharmacology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim |
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| Abstract: | In view of association of diabetes mellitus and male infertility, present study was designed to investigate the functional
status of hypothalamic pituitary gonadal (HPG) axis in diabetic men. Thirty-five diabetic men (BMI 22.24±0.21) in the age
group 20–40 (30.6±4.7) years were selected. Twenty-five healthy men (BMI 23.85±0.25), in the same age group (29.5±4.8) served
as control. Blood samples were collected for hormonal and biochemical estimations. Diabetic men had significantly low serum
testosterone with low LH and FSH, hypercholesterolemia, hypertriglyceridemia, hypoalbuminemia and increased oxidative stress.
Low serum testosterone in diabetic men was accompanied by low LH and FSH; the inability of the pituitary gland to respond
appropriately to a decline in testosterone implying central effect of high serum glucose on the interaction between the nervous
and endocrine system. Nutritional deficiency, increased oxidative stress and increased aromatase activity due to excessive
body fat might have also contributed to low serum testosterone. |
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| Keywords: | Diabetes Mellitus Testosterone Hypothalamic-pituitary-gonadal axis Oxidative stress |
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