Reversal of haemodialysis induced hypertriacylgycerolemia by L-carnitine |
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| Authors: | D K Srivastava S Kumar A P Misra |
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| Institution: | 1. Post Graduate Department of Medicine, GSVM Medical College, 208002, Kanpur
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| Abstract: | A 24 week follow-up study on lipid change following maintenance haemodialysis (MHD) in 25 chronic renal failure (CRF) patients
revealed significantly raised serum Triacylglycerol (TAG) levels in these cases (P<0.001), while cholesterol and HDL-Cholesterol
did not show any significant change, the extent of increase was 10.5±3.6% after 12 weeks and 23.0±5.8% after 24 weeks. Corresponding
increase in CRF patients treated conservatively, without haemodialysis, were 3.1±1.2% and 7.2±2.7% at these intervals. Subsequent
oral administration of L-Carnitine (5mg/kg body weight twice a day) for three weeks brought about a significant reversal of
elevated serum TAG level in MDH group as well as in the conservatively treated group (P≤0.05).
It is concluded that the haemodialysis induced Hyper-Triacylglycerolemia of CRF patients is revertible by Carnitine replenishment.
Even the concomitant increase in conservatively treated group is revertible by carnitine administration. |
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| Keywords: | Maintenance haemodialysis Carnitine Triacylglycerol Chronic renal failure |
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