Comparing age-wise reference intervals for serum creatinine concentration in a “Reality check” of the recommended cut-off |
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| Authors: | Mascha Verma Rashmi Khadapkar Priyadarshi Soumyaranjan Sahu Bibhu Ranjan Das |
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| Institution: | (1) Research and Development Division, SRL-Ranbaxy Limited (Clinical Reference Laboratories), 113, 15th Street, MIDC, Andheri (East), 400093 Mumbai, India |
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| Abstract: | An increase in the communication within the healthcare services, both nationally and internationally, has strengthened the
need for harmonization of measurements and reference intervals in laboratory medicine. In the present report, the calculated
reference interval for serum creatinine (sCr) levels of healthy normal individuals (n=1121) in different sex and age groups
are compared with the established interval. The calculated reference interval for sCr level was 0.4–1.3 mg/dL and 0.6 to 1.3
mg/dL in the age groups of 21–40 and 41–60 years respectively. The difference between the mean sCr values in total males and
total females (age range 21–60 years) was statistically significant (p<0.0001); When male and female subjects were analyzed
age-group wise, the data showed a significant difference in mean sCr values (p<0.0001) in three age groups (21–30, 31–40 and
41–50 years) however, in older age group (51–60 years), the difference was non-significant (p=0.07). The reference ranges
were 0.7–1.3 and 0.4–1.0 mg/dL for males and females respectively where the lower limit was 0.1–0.2 units less than that of
standard limits. An increase in the mean value of sCr was observed particularly in females with an increase in age. Hence
it is of interest to validate an age specific reference ranges for sCr in our population. |
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| Keywords: | sCr Reference Range Validation Glomerular Filtration Rate Clinical Reference Laboratory |
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