Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease |
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| Authors: | Jun Y Cho Dae Y Hwang Tae S Kang Dong H Shin Jin H Hwang Chae H Lim |
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| Institution: | 1. Division of Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA , Seoul, 122-704, Korea;2. Department of Exercise Biochemistry , Korea National University of Physical Education , Seoul, 138-763, Korea;3. Division of Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA , Seoul, 122-704, Korea |
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| Abstract: | In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on Aβ-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of Aβ-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease. |
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| Keywords: | Alzheimer's disease cholesterol exercise presenilin sports transgenic |
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