Heart rate and perceived muscle pain responses to a functional walking test in McArdle disease |
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| Authors: | John P Buckley Ros M Quinlivan Julius Sim Roger G Eston Deborah S Short |
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| Institution: | 1. Department of Clinical Sciences and Nutrition, University of Chester, Chester, UKj.buckley@chester.ac.uk;3. MRC Centre for Neuromuscular Diseases, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK;4. Health Services Research Unit, Keele University, Staffordshire, UK;5. School of Health Sciences, University of South Australia, Adelaide, Australia;6. The Wolfson Centre for Inherited Neuromuscular Disease, Robert Jones and Agnes Hunt Orthopaedic NHS Trust, Oswestry, UK |
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| Abstract: | AbstractThe aim of this study was to assess a 12-min self-paced walking test in patients with McArdle disease. Twenty patients (44.7 ±11 years; 11 female) performed the walking test where walking speed, distance walked, heart rate (HR) and perceived muscle pain (Borg CR10 scale) were measured. Median (interquartile range) distance walked was 890 m (470–935). From 1 to 6 min, median walking speed decreased (from 75.0 to 71.4 m?min–1) while muscle pain and %HR reserve increased (from 0.3 to 3.0 and 37% to 48%, respectively). From 7 to 12 min, walking speed increased to 74.2 m?min–1, muscle pain decreased to 1.6 and %HR reserve remained between 45% and 48%. To make relative comparisons, HR and muscle pain were divided by walking speed and expressed as ratios. These ratios rose significantly between 1 and 6 min (HR:walking speed P = .001 and pain:walking speed P < .001) and similarly decreased between 6 and 11 min (P = .002 and P = .001, respectively). Peak ratios of HR:walking speed and pain:walking speed were inversely correlated to distance walked: rs (HR) = ?.82 (P < .0001) and rs (pain) = ?.55 (P = .012). Largest peak ratios were found in patients who walked < 650 m. A 12-min walking test can be used to assess exercise capacity and detect the second wind in McArdle disease. |
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| Keywords: | Borg’s pain scale second-wind 12-min walk test |
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