| 低氧运动对大鼠心肌闰盘及其线粒体ATP酶的作用 |
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| 引用本文： | 李彤.低氧运动对大鼠心肌闰盘及其线粒体ATP酶的作用[J].北京体育大学学报,2009(9). |
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| 作者姓名： | 李彤 |
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| 作者单位： | 沈阳大学体育学院; |
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| 基金项目： | 辽宁省教育厅科学技术研究项目(编号:2009A670) |
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| 摘 要： | 目的:研究急性低氧运动和慢性间歇低氧训练对大鼠心肌心室闰盘和心肌线粒体ATP酶的影响,旨在探讨心肌低氧适应的机制,为高原训练方案的制定提供理论依据。方法:采用透射电镜技术观察大鼠心肌心室闰盘超微结构在低氧适应过程中的变化,同时用分光光度法测定心肌线粒体Na~+K~+、Ca~(2+)、Mg~(2+)和Ca~(2+)Mg~(2+)四种ATP酶的活性。结果:急性低氧运动可造成心肌超微结构的损伤,Na~+K~+-ATPase和Ca~(2+)-ATPase明显下降;经过4周的运动训练后再进行低氧应激,心肌的损伤减轻,线粒体ATP酶的活性都显著升高。结论:急性运动后进入急性低氧应激,导致心肌损伤加重,是由于运动缺氧损伤和低氧损伤双重作用的结果,而长期间歇低氧训练可减轻低氧环境心肌的损伤,能量代谢得到改善。
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| 关 键 词： | 低氧运动 闰盘 ATP酶 |
Effects of Hypoxia Training on Rats' Myocardial Ultrastructure of Intercalated Disc and Mitochondrial ATPase |
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| LI Tong.Effects of Hypoxia Training on Rats' Myocardial Ultrastructure of Intercalated Disc and Mitochondrial ATPase[J].Journal of Beijing Sport University,2009(9). |
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| Authors: | LI Tong |
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| Institution: | LI Tong (Sports School,Shenyang University,Shenyang 110032,Liaoning China) |
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| Abstract: | Objective:to study the effects of acute and chronic intermittent hypoxia training on myocardial ultrastructure of intercalated disc and mitochondrial ATPase.Methods:Myocardial ultrastructure of intercalated disc are observed by transmission electron microscope,meanwhile the activities of Na~+ K~+,Ca~(2+),Mg~(2+) and Ca~(2+) Mg~(2+) ATPase are tested.Results: acute hypoxic stress can induce myocardial ultrastructure damage and the activity of ATPase decreases.The damages to the rats exposed to hypoxia with 4... |
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| Keywords: | hypoxia training intercalated disc ATPase |
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