This research is distinctive in that it not only provides an example of one of the few cross-cultural studies in science education, but also it used multiple research methods from different paradigms in exploring classroom learning environments in Taiwan and Australia. This article describes the validation and use of an English and Mandarin version of the What is Happening in this Class? (WIHIC) questionnaire in junior high school science classes in Australia and Taiwan. When the WIHIC was administered to 1,081 students in 50 classes in Australia and to 1,879 students in 50 classes in Taiwan, data analysis supported the reliability and factorial validity of the questionnaire, and revealed differences between Taiwanese and Australian classrooms. Although the study commenced from a more positivistic framework, favouring a more objectivist view, as the study progressed, it employed an interpretative framework and drew on elements of constructivist and critical theory paradigms. This article outlines the researchers' use of multiple research methods including classroom observations, in-depth interviews and narratives. The themes which emerged from the data gathered using these methods helped to make sense of classroom environments that were created in each country.