| Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction |
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| 作者姓名： | 罗本燕 陈智 陈峰 李霞 潘小平 |
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| 作者单位： | Department of Neurology，Institute of Infectious Diseases，Institute of Infectious Diseases，Department of Neurology，Institute of Infectious Diseases The First Affiliated Hospital，Medical College，Zhejiang University，Hangzhou 310003，China，The First Affiliated Hospital，Medical College，Zhejiang University，Hangzhou 310003，China，The First Affiliated Hospital，Medical College，Zhejiang University，Hangzhou 310003，China |
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| 基金项目： | Project (No .2 0 0 0B0 76)supportedbytheBureauofPublicrlealthofZhejiangProvince |
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| 摘 要： | INTRODUCTIONAtheroscleroticCerebralInfarction (ACI)isoneofthemostcommoncerebralvasculardis easse.Itspathogenesishasnotyetbeencom pletelyexpounded ,althoughmoreandmorestudiesshowingthatgeneticfactorsmayplayanimportantrole ,especiallygeneticmutations.Lo cat…
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Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction |
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| Abstract: | Objective: To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group ( P = 0.011) . Conclusions: 465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI. |
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| Keywords: | Cerebral infarction Atherosclerotic Genetics ApoE allele Single nucleotide polymorphism |
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