Effects of moniliformin and selenium on human articular cartilage metabolism and their potential relationships to the pathogenesis of Kashin-Beck disease |
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| Authors: | An Zhang Jun-ling Cao Bo Yang Jing-hong Chen Zeng-tie Zhang Si-yuan Li Qiang Fu Clare E Hugnes and Bruce Caterson |
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| Institution: | (1) Department of Bioregulation and Proteomics, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan;(2) Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan |
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| Abstract: | Objective:To investigate the effects of mycotoxin moniliformin (MON) on the metabolism of aggrecan and type II collagen in human chondrocytes in vitro and the relationship between MON and Kashin-Beck disease (KBD).Methods:Human chondrocytes were isolated and cultured on bone matrix gelatin to form an artificial cartilage model in vitro with or without MON toxin.Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.The expression of aggrecan and type II col... |
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| Keywords: | Chondrocytes Moniliformin Selenium Aggrecan Collagen Matrix metalloproteinases (MMPs) CD44 Kashin-Beck disease |
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