| 大鼠实验性胃溃疡自愈期间肾上腺髓质CgA免疫细胞的研究 |
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| 引用本文： | 王海萍,任君旭,周济远,吴靖芳,张静,郑慧娥,张耕,王新生.大鼠实验性胃溃疡自愈期间肾上腺髓质CgA免疫细胞的研究[J].河北北方学院学报(医学版),2002,19(5):6-8. |
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| 作者姓名： | 王海萍 任君旭 周济远 吴靖芳 张静 郑慧娥 张耕 王新生 |
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| 作者单位： | 1. 张家口医学院组胚教研室,075000
2. 张家口医学院解剖教研室,075000 |
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| 摘 要： | 目的 :探讨大鼠实验性胃溃疡自愈期间肾上腺髓质嗜铬颗粒素A(CgA)免疫反应细胞的变化。方法 :采用免疫组织化学方法 (SP法 )显示阳性细胞并用病理图像分析系统软件做面密度分析。结果 :溃疡组CgA阳性细胞面密度与正常组相比于术后 4d、6d、10d、14d低于正常组 ,均为P <0 .0 1,以 4d最显著。溃疡组CgA阳性细胞面密度于术后 6d、10d低于盐水组 ,均为P <0 .0 1。结论 :肾上腺髓质CgA阳性细胞可能间接或直接参与大鼠实验性胃溃疡修复的调节。
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| 关 键 词： | 大鼠 胃溃疡 肾上腺髓质 嗜铬颗粒素A |
| 文章编号： | 1005-8796(2002)05-06-03 |
The immunohistochemical study on CgA positive cells in adrenal medulla of rats during the self- healing process of experimental gastric ulcer |
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| Wang Haiping,Ren Junxu,Zhou Jiyuan,et al Zhangjiakou Medical College,Zhangjiakou,China.The immunohistochemical study on CgA positive cells in adrenal medulla of rats during the self- healing process of experimental gastric ulcer[J].Journal of Hebei North University:Medical Edition,2002,19(5):6-8. |
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| Authors: | Wang Haiping Ren Junxu Zhou Jiyuan Zhangjiakou Medical College Zhangjiakou China |
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| Institution: | Wang Haiping,Ren Junxu,Zhou Jiyuan,et al Zhangjiakou Medical College,Zhangjiakou,075000,China |
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| Abstract: | Objective:To strdy on the changes of CgA immunoreactive cells in adrenal medulla of rats during the self- healing process of experimental gastric ulcer.Methods:The immunohistochemical SP method was used to show CgA positive cells. The analytical software of pathological image was used in the sdanalysis.Reasults: The surface densities on area of CgA cells were decreased on 4th?6th ? 10th and 14th days after operation in gastric ulcer group compared with the normal group (P<0.01).The surface density of CgA cells on the 4th day decreased significantly than that of normal group.The surface density of CgA positive cells in gastric ulcer group decreased than that of saline group on the 6th and 10th days after operation(P< 0.01) . Conclusion: The present work proved that the CgA cells of adrenal medulla or indirectly participated in the regulative balance of endocrine during the self-healing directly of the experimental gastric ulcer and here we provide morphological evidence. |
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| Keywords: | Rat Gastric ulcer Adrenal medulla Chromogranin A |
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