| 新型常山碱类抗球虫化合物的合成 |
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| 引用本文： | 严春蓉,吕春兰,徐慎颖,李慧.新型常山碱类抗球虫化合物的合成[J].宜宾学院学报,2012(6):54-56. |
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| 作者姓名： | 严春蓉 吕春兰 徐慎颖 李慧 |
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| 作者单位： | 1. 宜宾学院化学与化工学院,四川宜宾,644000
2. 宜宾学院外国语学院,四川宜宾,644000 |
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| 基金项目： | 国家自然科学基金资助项目(21072135);宜宾学院博士科研启动项目(2010B09) |
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| 摘 要： | 通过 2-溴-N-（2-硝基苯）乙酰胺和取代的喹唑啉酮在 NaH 催化下发生亲核取代反应，再经过氢化、酸化合成了 2 个新型常山碱类抗球虫药物——N-（2-氨基苯基）-2-喹唑啉酮乙酰胺盐酸盐．其中 2-溴-N-（2-硝基苯）乙酰胺通过溴乙酰氯与邻硝基苯胺反应制备，取代的喹唑啉酮使用取代的邻氨基苯甲酸与甲酰胺反应合成．化合物的合成具有合成路线短、产率高、原料易得等优点．目标化合物的结构均经1H NMR，IR 和 HRMS 等方法确证.
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| 关 键 词： | 2-溴-N-(2-硝基苯)乙酰胺 取代的喹唑啉酮 常山碱类抗球虫药物 N-(2-氨基苯基)-2-喹唑啉酮乙酰胺盐酸盐 合成 |
Synthesis of Novel Febrifugine Anticoccidial Compounds |
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| Authors: | YAN Chun-rong LV Chun-lan XU Shen-ying LI Hui |
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| Institution: | 1.College of Chemistry and Chemical Engineering;Yibin University,Yibin 644000,China;2.College of Foreign Languages and Literature,Yibin University,Yibin 644000,China) |
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| Abstract: | Tow novels N-(2-aminophenyl)-2-quinazolinone-acetamide hydrochloride were synthesized through nucleophilic substitution,hydrogenation and acidification.The nucleophilic substitution was reacted between 2-bromo-N-(2-nitrophenyl)acetamide and various substituted quinazolinone under the catalysis of NaH.Among them,2-bromo-N-(2-nitrophenyl)acetamide was synthesized by a reaction between acetyl chloride and o-nitroaniline.And the substituted quinazolinone was synthesized by using aminobenzoic acid and formamide.The new process is characterized by short synthetic route,high yield and cheap raw materials.The structures of these compounds were confirmed by 1H NMR,IR spectra and HRMS. |
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| Keywords: | 2-bromo-N-(2-nitrophenyl)acetamide substituted quinazolinone febrifugine anticoccidial compound N-(2-aminophenyl)-2-quinazolinone-acetamide hydrochloride synthesis |
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