| 布洛芬的拆分工艺改进 |
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| 引用本文： | 王洪林,董世昌,李立威.布洛芬的拆分工艺改进[J].荆门职业技术学院学报,2010,25(9):9-11. |
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| 作者姓名： | 王洪林 董世昌 李立威 |
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| 作者单位： | 荆楚理工学院,化工与药学院,湖北,荆门,448000 |
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| 摘 要： | 以（S）-（-）-α-苯乙胺为拆分剂,水为拆分溶剂,用消旋布洛芬为原料拆分制备右旋布洛芬,一次拆分收率为32%。将左旋布洛芬制成其钾盐的水溶液,在常压下加热消旋。
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| 关 键 词： | 布洛芬 （S）-（-）-α-苯乙胺 拆分 右旋布洛芬 消旋 |
A Improved Resolution Process of Ibuprofen |
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| WANG Hong-lin,DONG Shi-chang,LI Li-wei.A Improved Resolution Process of Ibuprofen[J].Journal of Jingmen Vocational Technical College,2010,25(9):9-11. |
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| Authors: | WANG Hong-lin DONG Shi-chang LI Li-wei |
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| Institution: | (Department of Chemical and Pharmaceutical,Jingchu University of Technology,Jingmen,Hubei,448000,China) |
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| Abstract: | Taking the（s）-（-）-α-phenylethylamine as resolving agent,water as resolution solvent and racemic Ibuprofen as material resolved to make Dexibuprofen was effective.Each resolution yield was 32%.The L-Ibuprofen was made into aqueous solution of its potassium salt and racemized at normal pressure. |
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| Keywords: | Ibuprofen （S）-（-）-α-phenylethylamine resolution Dexibuprofen racemization |
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