| 线粒体基因突变糖尿病的临床研究进展 |
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| 引用本文： | 于萌.线粒体基因突变糖尿病的临床研究进展[J].大连大学学报,2008,29(3):99-101. |
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| 作者姓名： | 于萌 |
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| 作者单位： | 大连大学,附属中山医院,辽宁,大连,116001 |
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| 摘 要： | 线粒体基因突变糖尿病的发现是近年来糖尿病分子遗传学研究的重要进展之一，也是近年来糖尿病研究的一大热点。线粒体tRNA^leu（uuR）A3243G突变导致胰岛B细胞功能缺陷，进而导致线粒体糖尿病的发生。WHO已将此型糖尿病归类为特殊类型糖尿病。综述此型糖尿病的临床表现及其分子诊断学方法和临床研究进展。
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| 关 键 词： | 线粒体基因 基因突变 糖尿病 |
| 文章编号： | 1008-2395(2008)03-0099-03 |
| 修稿时间： | 2007年4月12日 |
Reviews in Clinical Studies on Mitochondrial Diabetes |
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| YU Meng.Reviews in Clinical Studies on Mitochondrial Diabetes[J].Journal of Dalian University,2008,29(3):99-101. |
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| Authors: | YU Meng |
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| Institution: | YU Meng (Affiliated Zhongshan hospital of Dalian University, Dalian 116001, China) |
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| Abstract: | Diagnosis of mitochondrial gene mutation-associated diabetes has been considered as a significant achieve- ment in molecular and genetic study on diabetes,which remains an important issue in diabetic study.In the large majority of cases,an A3243G mutation in the mitochondriai DNA-encoded tRNA~(Leu,UUR) leads to pancreatic beta cell dysfunction,which contributes to the development of mitochondrial diabetes,a pancreatic beta cell dysfunction- associated specific type of diabetes defined by WHO. |
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| Keywords: | Mitochondrial gene Gene mutation Diabetes mellitus |
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