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大剂量纳络酮治疗重型颅脑损伤
引用本文:许伟,卢晓敏,黄李法.大剂量纳络酮治疗重型颅脑损伤[J].科技通报,2002,18(4):337-339.
作者姓名:许伟  卢晓敏  黄李法
作者单位:1. 浙江省省级医疗保险服务中心,浙江,杭州,310007
2. 杭州市第四人民医院,浙江,杭州,310002
摘    要:目的 探讨纳络酮对重型颅脑损伤患者的疗效。方法 将同期收治的60例重型颅脑损伤患者随机分为治疗组(纳络酮治疗)和对照组各30例,对两组患者的GCS(格拉斯哥评分)及GOS(格拉斯哥预后评分)计分进行对比分析。结果 治疗组患者的GCS计分及GOS计分在治疗后及随访时均较对照组有所提高,结果有显著性差异(P<0.05)。结论 早期大剂量使用纳络酮对改善急性重症颅脑损伤病人的预后有明显的疗效。

关 键 词:颅脑损伤  纳络酮  β-内啡肽  药物治疗
文章编号:1001-7119(2002)04-0337-03
修稿时间:2001年10月27

Clinical Effect of Naloxone on Patients with Severe Craniocerebral Injury
XU We ,LU Xiao min ,HUANG Li fa.Clinical Effect of Naloxone on Patients with Severe Craniocerebral Injury[J].Bulletin of Science and Technology,2002,18(4):337-339.
Authors:XU We  LU Xiao min  HUANG Li fa
Institution:XU We 1,LU Xiao min 2,HUANG Li fa 2
Abstract:To explore the therapeutic effection of naloxone on the treatment of patients of the severe with craniocerebral injury. 60 patients with severe brain injury were randomly divided into the treatment group (used with the naloxone)and the control group. GCS and GOS were analysed comparatively. In comparison with control group both of GCS and GOS were increased evidently in treatment group ( P <0.05). Early administration of high dose of naloxone is safe and more effective for the patients with severe craniocerebral injury.
Keywords:craniocerebral injury  naloxone  beta  endorphin
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