Diagnosis of acute myocardial infarction: CK-MB versus cTn-T in Indian patients |
| |
| Authors: | Sanjiv Gupta K N Singh V Bapat V Mishra D K Agarwal P Gupta |
| |
| Institution: | (1) Department of Physiology, MLN Medical College, C/o Mrs. Priti Gupta 403/Type 4, M.L.N. Medical College Campus, Allahabad, India;(2) Division of Cardiology of Medicine SRN Hospital, MLN Medical College, C/o Mrs. Priti Gupta 403/Type 4, M.L.N. Medical College Campus, Allahabad, India |
| |
| Abstract: | The comparative diagnostic efficacy of two cardiac markers: CK-MB and cTn-T, has scarcely been investigated in Indian patients
of acute myocardial infarction. The present study was conducted for the same objective. The present study comprised of 59
patients. Males were 44 (75%) and females were 15 (25 %). The age of patients ranged from 32–84 years with mean age of 62.8
yrs. The mean age of males and females were 60 and 63 yrs respectively. All patients presented with history of chest pain
with a 12 leads ECG proven MI (ST Elevation, discordant T-waves). CK-MB was estimated in peripheral blood samples at 0,24,48
and 72 hours by an autoanalyzer. Following 12 hours of admission bed side Troponin-T test was done employing cTn-T marker
kit. Initially (0 hr), in 50% patients CK-MB was elevated. By end of 24 hours all the patients were CKMB positive and peak
level was attained at 24 hrs. Then it tended to decline over next 48 hrs. There were no false positive or negative results.
The cTn-T test was positive only in 22 % of ECG positive infarctions. However, the cTn-T positive cases were always accompanied
by a higher CK-MB levels. A significantly lower cTn-T positive cases in Indian patients can only be attributed to some difference
in amino acid sequence of Indian cTn-T and occidental cTn-T. A larger study from other Indian cardiac centers can either substantiate
or contradict our results. |
| |
| Keywords: | Acute Myocardial Infarction CK-MB cTn-T |
| 本文献已被 SpringerLink 等数据库收录！ |
|
