Altered maternal thyroid function: Effect of L-carnitine supplementation on fetal and neonatal myocardial free fatty acid oxidation,in vitro |
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| Authors: | Ratan Kumar |
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| Institution: | (1) Department of Biochemistry, Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, 110054 Delhi |
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| Abstract: | Effect of L-carnitine supplementation on myocardial free fatty acid oxidation,in vitro, in offsprings born of hypothyroid and hyperthyroid mothers was studied in rats. L-carnitine supplementation stimulated myocardial
fatty acid oxidation during gestational period in offspring born of control and hyperthyroid mothers. In contrast L-carnitine
supplementation induced stimulation in myocardial fatty acid oxidation was very less in fetuses born of hypothyroid mothers.
However, in neonates born of hypothyroid mothers L-carnitine stimulated myocardial fatty acid oxidation to a great extent.
The results suggested that during maternal hypothyroidism low availability of thyroid hormones to fetuses through maternal
circulation and availability of less carnitine to neonates due to hypolactation might be responsible for decreased myocardial
free fatty acid utilization. In neonates born of hypothyroid mothers and with cardiac energy insufficiency parenteral carnitine
supplementation might be of great help to prevent mortality and morbidity of such offsprings. |
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| Keywords: | Maternal Thyroid Fetal Heart FFA |
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