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急性脑缺血治疗药物研究进展
引用本文:张雯,宋俊科,杜立达,张雪,杜冠华.急性脑缺血治疗药物研究进展[J].河北北方学院学报(医学版),2014(4):50-58.
作者姓名:张雯  宋俊科  杜立达  张雪  杜冠华
作者单位:中国医学科学院&北京协和医学院药物研究所、北京市药物靶点研究与新药筛选重点实验室,中国北京100050
基金项目:国家“重大新药创制”科技重大专项项目(No.2012ZX09103-101-078);国家“重大新药创制”科技重大专项项目(No.2013ZX09102106)
摘    要:急性脑缺血是目前严重威胁人类健康的重大疾病,其病理生理机制复杂,临床治疗应用的药物非常有限,而且作用特点和效果仍不明确。该文总结了目前我国临床用于治疗急性脑缺血药物的作用和机制,比较了各种药物的特点,结合近年来国内外抗急性脑缺血药物研究的进展,探讨了治疗急性脑缺血药物的发展前景。

关 键 词:脑缺血  神经保护  溶栓

Advances in Pharmacologic Treatment of Acute Cerebral Ischemia
ZHANG Wen,SONG Jun-ke,DU Li-da,ZHANG Xue,DU Guan-hua.Advances in Pharmacologic Treatment of Acute Cerebral Ischemia[J].Journal of Hebei North University:Medical Edition,2014(4):50-58.
Authors:ZHANG Wen  SONG Jun-ke  DU Li-da  ZHANG Xue  DU Guan-hua
Institution:(Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China)
Abstract:Acute cerebral ischemia is one of the most threating diseases to human health, with extremely complex pathophysiology. Considering the limited number of anti-cerebral ischemia drugs and their unclear mechanisms, there are almost no ideal therapeutic drugs in clinical. In this paper,we summarized the function characteristics of current clinical drugs, compared their efficacy, reviewed the related articles at home and abroad in recent years, and elaborated the research situation of various tvnes of anti-cerehral ischemia drugs.
Keywords:cerebral ischemia  neuroprotection  thrombolysis  
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