Curative effect of <Emphasis Type="Italic">Cynodon dactylon</Emphasis> against STZ induced hepatic injury in diabetic rats |
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| Authors: | Santosh Kumar Singh Prashant Kumar Rai Shikha Mehta Rakesh Kumar Singh Geeta Watal |
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| Institution: | (1) Ecology, Taxonomy and Nature Conservation Centre, Institute of Biology, Romanian Academy, Spl. Independentei 296, Sector 6, 060031 Bucharest, Romania |
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| Abstract: | The aim of the study was to ascertain the role of ethanolic extract of Cynodon dactylon against hepatic complications in streptozotocin
(STZ) induced type 2 diabetic models. Effect of the pre identified most effective dose of 500 mg/kg body weight was studied
on hepatic injury caused by chemically induced diabetes by 55 mg/kg body weight i.p. injection of STZ in male Wistar rats.
The dose of 500mg/kg body weight given once daily for 14 days reduced the levels of serum glutamate oxaloacetate transaminase,
serum glutamate pyruvate transaminase, alkaline phosphatase, creatinine and urine sugar significantly (P<0.05) with increase
in total protein, haemoglobin and body weight was increased. High LD50 validates its high margin of safety. |
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