Protective role of N-acetylcysteine against alcohol and paracetamol induced toxicity |
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| Authors: | D S Jaya J Augustine V P Menon |
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| Institution: | 1. Department of Biochemistry, University of Kerala, 695581, Trivandrum
2. Department of Pathology, Medical College, 695581, Trivandrum
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| Abstract: | The effect of administration of N-acetylcysteine on ethanol and paracetamol induced hepatotoxicity was studied both biochemically
and histopathologically in experimental rats. The liver samples taken after twentyfour hours from the paracetamol administered
normal and alcoholic animals showed high degree of necrosis and related pathological changes. In the N-acetylcysteine treated
alcoholic rats and in the N-acetylcysteine pretreated paracetamol administered rats, the liver cells showed very little change
and appeared almost normal as evidenced by the histopathological studies. The activities of serum transaminases and phosphatases
were also high both in the alcohol treated and in the paracetamol administered animals. N-acetylcysteine treated animals partly
restored the serum transaminase and phosphatase activities, and the activities of the antiperoxidative enzymes. There was
also significant change in the serum and tissue lipid levels, and in the concentration of the tissue lipid peroxidation product-malondialdehyde
in both the alcohol treated and in the paracetamol administered groups. N-acetylcysteine treatment brought the serum and tissue
lipid levels, and the tissue malondialdehyde content towards normal. |
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| Keywords: | alcohol hepatotoxicity lipids malondialdehyde N-acetylcysteine necrosis paracetamol |
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