Correlation of Microalbuminuria with
Estimated GFR (eGFR) by Cockcroft–Gault and MDRD Formula in Type 2 Diabetics and
Hypertensives |
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| Authors: | T K Saha Arabinda Mohan Bhattarai H S Batra Mithu Banerjee Pratibha Misra Vivek Ambade |
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| Institution: | Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040 Maharashtra India |
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| Abstract: | Increase in urine albumin excretion rate (AER) precede a fall in glomerular
filtration rate in patients developing diabetic chronic kidney disease (CKD). Our
results have shown that 7 (50 %) of diabetic and hypertensive individuals with
decreased GFR do not have increased AER. In this cross-sectional study, we measured
AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric
method. We correlated the results with eGFR values obtained by Cockcroft–Gault and
MDRD method. The method used was not a compensated method. We measured serum
creatinine by modified Jaffe’s kinetic method in autoanalyzer XL-600. Analysis of
data showed positive correlation between eGFR and microalbuminuria by both the
methods with eGFR <60 mL/min/1.73 m2. Pearson’s
correlation co-efficient (r) was 0.9 (p = 0.0001)
by Cockcroft–Gault formula and 0.69 (p = 0.0063)
by MDRD formula. Our results concluded that there was positive correlation between
AER and eGFR <60 mL/min/1.73 m2. We have recognized
that these two parameters provide a complimentary benefit in management of cases
with CKD. |
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| Keywords: | eGFR Cockcroft– Gault Modification of diet in renal disease Albumin excretion rate |
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