Biochemical Profile of Nonalcoholic Fatty Liver Disease Patients in Eastern India with Histopathological Correlation |
| |
| Authors: | Manorama Swain Preetam Nath Prasant Kumar Parida Jimmy Narayan Pradeep Kumar Padhi Girish Kumar Pati Ayaskanta Singh Bijay Misra Debasis Misra Sanjib Kumar Kar Manas Kumar Panigrahi Chudamani Meher Omprakash Agrawal Niranjan Rout Kaumudee Pattnaik Pallavi Bhuyan Pramila Kumari Mishra Shivaram Prasad Singh |
| |
| Institution: | 1.Department of Biochemistry,S.C.B. Medical College,Cuttack,India;2.Department of Gastroenterology,S.C.B. Medical College,Cuttack,India;3.Department of Gastroenterology,IMS and SUM Hospital,Bhubaneswar,India;4.Department of Gastroenterology,Institute of Gastro and Kidney Care,Bhubaneswar,India;5.Department of Radiology,Beam Diagnostics Centre,Cuttack,India;6.Department of Oncopathology,Acharya Harihara Regional Cancer Center,Cuttack,India;7.Department of Pathology,S.C.B. Medical College,Cuttack,India;8.Department of Biochemistry,M.K.C.G. Medical College,Berhampur,India |
| |
| Abstract: | Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in nonalcoholic fatty liver disease (NAFLD). Aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD. Single center observational study was conducted in a gastroenterology clinic at Cuttack in coastal Odisha. Subjects were consecutive patients presenting with functional bowel disease and undergoing abdominal sonography. All participants were evaluated for the presence of metabolic syndrome (MS), insulin resistance, liver function test and lipid profile. Various parameters were compared between NAFLD subjects and controls. 53.5 % of NAFLD had normal serum transaminases, whereas 20.8 % of healthy controls had transaminitis. NAFLD patients had significantly higher BMI, fasting plasma glucose, serum transaminases, serum triglycerides, serum insulin and homeostatic model assessment (HOMA) IR than controls. NAFLD patients who had transaminitis had significantly higher incidence of MS and higher mean HOMA IR than those without. There was no significant difference in histopathological features between NAFLD with and without transaminitis. To conclude, over half of NAFLD subjects do not have transaminitis while transaminitis is present in a fifth of healthy people without fatty liver. Hence serum transaminase should not be used as screening test for NAFLD. NAFLD patients with transaminitis had a higher incidence of MS and insulin resistance than those without. However, there was no significant difference in histopathological features between these two groups. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
