Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital |
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| Authors: | Bhawna M Singh B Goswami V Mallika |
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| Institution: | 1.Department of Biochemistry,G B Pant Hospital,New Delhi,India;2.Department of Biochemistry,G B Pant Hospital,New Delhi,India |
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| Abstract: | The effect of thyroid status on insulin sensitivity is of great interest but despite various studies there is conflicting
data on this subject. The study group comprised of 25 female subjects each with subclinical hypothyroidism, overt hypothyroidism
and euthyroid controls. Serum samples of all the patients were assayed for thyroid profile, Insulin and lipid profile. Homeostasis
model of assessment (HOMA-IR) was employed to assess the level of insulin resistance. Patients with hypothyroidism demonstrated
insulin resistance and dyslipidemia as observed by the higher HOMA-IR and cholesterol and triglyceride levels respectively
as compared to the controls. A significantly positive correlation between TSH and HOMA-IR level was also observed in the hypothyroidism
group. Thyroid dysfunction leads to alterations in glucose and lipid metabolism which is an important risk factor for cardiovascular
diseases. The dyslipidemia and insulin resistance should be managed aggressively to reduce the impending risk. |
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