| 肾病综合征患者血浆脂蛋白(a)水平相关性分析 |
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| 引用本文： | 闫智宏,徐志伟,梁庆智.肾病综合征患者血浆脂蛋白(a)水平相关性分析[J].河北北方学院学报(医学版),2007,24(1):12-14. |
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| 作者姓名： | 闫智宏 徐志伟 梁庆智 |
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| 作者单位： | 1. 河北北方学院生化教研室,河北,张家口,075000
2. 河北省张家口市第一医院内科,河北,张家口,075000 |
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| 摘 要： | 目的：研究血浆脂蛋白（a）Lp（a）]水平与肾病综合征（NS）的关系，探讨Lp（a）在肾病综合征合并心脑血管疾病中的作用。方法：用酶联免疫吸附法分别测定了61例肾病综合征患者与55名健康对照者的Lp（a）浓度，并同时测定了BUN、Scr、TG、TC、LDL-C和HDL-C的含量。结果：肾病综合征患者Lp（a）、BUN、Scr、TC、LDL-C水平均明显高于正常对照组。而HDL-C显著低于对照组，NS组Lp（a）浓度与BUN和Scr呈显著正相关，Lp（a）水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性。结论：肾病综合征患者体内存在着Lp（a）等脂代谢紊乱的情况，高血浆Lp（a）水平是肾病综合征合并心脑血管疾病的独立危险因素之一。
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| 关 键 词： | 脂蛋白(a) 肾病综合征 酶联免疫吸附法 |
| 文章编号： | 1673-1484(2007)01-0012-03 |
Plasma Lipoprotein(a) Levels in Patients with Nephritic Syndrome and Healthy People |
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| YAN Zhi-hong,XU Zhi-wei,LIANG Qing-zhi.Plasma Lipoprotein(a) Levels in Patients with Nephritic Syndrome and Healthy People[J].Journal of Hebei North University:Medical Edition,2007,24(1):12-14. |
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| Authors: | YAN Zhi-hong XU Zhi-wei LIANG Qing-zhi |
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| Abstract: | Objective: To study the relationship between plasma lipoprotein(a) levels and the diseases of nephritic syndrome and investigate the clinical role of lipoprotein(a) in patients with cardiocerebrovascular arteriosclerosis caused by nephritic syndrome.Methods: Plasma concentrations of lipoprotein(a) were measured by enzyme-linked immunosorbent assay in 61 patients with nephritic syndrome and 55 healthy objects.At the same time the levels of BUN,Scr,TG,TC,LDL-C and HDL-C were measured with enzyme assay respectively.Results: The concentrations of Lp(a),BUN,Scr,TC and LDL-C in patients with nephritic syndrome were significantly higher than that in healthy controls,however the concentrations of HDL-C in patients with nephritic syndrome was significantly lower.The plasma concentration of lipoprotein(a) was significantly positive correlating with plasma BUN concentration and Scr concentration.There was no correlation between LDL-C,HDL-C,TG,TC and Lp(a).Conclusion: Nephritic syndrome exists the circumstance of the disorder of lipid metabolism,such as Lp(a) etc.The high level of Lp(a) is an independent risk factor for cardiocerebrovascular arteriosclerosis caused by nephritic syndrome. |
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| Keywords: | Lipoprotein(a) Nephritic syndrome Enzyme-linked immunosorbent assay |
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