Influence of systemic immune and cytokine responses during the acute phase of zoster on the development of postherpetic neuralgia |
| |
| Authors: | Sheng-mei Zhu Yong-min Liu Er-dan An Qing-lian Chen |
| |
| Institution: | (1) Department of Anesthesiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China;(2) Department of Anesthesiology, the Second People’s Hospital, Jiaxing, 314000, China |
| |
| Abstract: | Postherpetic neuralgia (PHN) is a severe sequela of herpes zoster (HZ). Until now, only age and pain severity were considered
predisposing factors for the development of PHN. We evaluated 49 patients with acute phase HZ, 10 of whom developed PHN (Group
A) and 39 of whom did not develop PHN (Group B). Twenty-five healthy volunteers similar in age and gender distribution to
the study group were recruited as controls (Group C). Numbers of serum CD3+ (pan-T lymphocytes), CD4+ (helper/inducer), and CD8+ (suppressor/cytotoxic) lymphocytes were decreased significantly in Groups A and B relative to the control group, but there
were no statistical differences between Groups A and B. Interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, IL-8, and
IL-10 were significantly elevated in Groups A and B relative to Group C. IL-6 was significantly higher in Group A than in
Group B, and was significantly positively correlated with pain severity scored on a visual analog scale. Therefore, we suggest
that the inflammatory response, especially that of IL-6, in the acute phase of HZ may be associated with hyperalgesia and
the development of PHN.
Project (No. 2008ZYC07) supported by the Zhejiang Medical Bureau of China |
| |
| Keywords: | T lymphocyte Cytokines Postherpetic neuralgia (PHN) Herpes zoster (HZ) |
| 本文献已被 万方数据 SpringerLink 等数据库收录！ |
|
