Changes in antioxidant enzyme levels and DNA damage during aging |
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| Authors: | K K Reddy T P K Reddy B V Somasekharaiah K Soorya Kumarl |
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| Institution: | (1) School of Biological & Earth Sciences, Department of Anthropology, Sri Venkateswara University, 517 502 Tirupati;(2) Department of Chemistry, St.Joseph's College, 560 001 Bangalore;(3) Department of Biochemistry, Siddartha Medical College, 520 004 Vijayawada |
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| Abstract: | Multiple mechanisms underlie the human aging process, but interest continues in the role that free radicals and antioxidants
may play. The concentrations of lymphocyte free radical generation (O2
−& H2O2), DNA damage and antioxidant enzyme levels (glutathione Stransferase, superoxide dismutase and catalase) were evaluated in
110 healthy individuals with an age range of 20–80 years. The antioxidant enzyme levels were significantly less in very old
age when compared to young. Moreover, the levels of free radical concentration and DNA damage were increased in the same age
group with respect to younger group. Cigarette smoking had a positive relation with free radicals and DNA damage, and inverse
relation with antioxidants. On the other hand, body mass was found to have positive relation with free radical generation
only. The data indicate that depletion of antioxidant enzyme levels would render the older people more susceptible to free
radical stress and DNA damage. |
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| Keywords: | Free radicals DNA damage Antioxidants Aging |
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