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| 运动对肥胖状态下LKB1-AMPK-ACC信号传导通路的影响 | |
| 引用本文： | 陈春平,任华,何柯书,常波.运动对肥胖状态下LKB1-AMPK-ACC信号传导通路的影响[J].广州体育学院学报,2012,32(4):101-104,113. |
| 作者姓名： | 陈春平 任华 何柯书 常波 |
| 作者单位： | 1. 广东培正学院体育教学部,广东广州,510530 2. 沈阳体育学院研究生部,辽宁沈阳,110102 3. 沈阳体育学院运动人体科学学院,辽宁沈阳,110102 |
| 基金项目： | 辽宁省高等学校优秀人才支持项目，国家自然科学基金项目:“运动干预改善2型糖尿病大鼠骨骼肌信号通路的机制研究” |
| 摘 要： | 肥胖已经成为危险人类健康的常见慢性疾病,而运动是目前公认的治疗肥胖最为有效的方法之一。AMPK(腺苷酸活化蛋白激酶)是一种比较重要的代谢性应激蛋白激酶,在全身的能量平衡中起着总开关的作用。LKB1可以活化细胞中的AMPK,AMPK使ACC(乙酰辅酶A羧化酶)磷酸化失活,脂肪酸合成减少、氧化分解增加,从而预防肥胖的发生发展。肥胖状态下,AMPK磷酸化水平降低,ACC活性增强,脂肪酸合成增加、氧化速率下降。而运动是改善肥胖的重要手段,可以使AMPK磷酸化增强,ACC活性减弱。主要阐述肥胖状态下LKB1-AMPK-ACC信号传导通路各级联蛋白的变化趋势,以及运动干预对各级联蛋白含量的影响。 |
| 关 键 词： | AMPK ACC LKB1 肥胖 运动 |
Effect of Exercise on LKB1 - AMPK - ACC Signal Pathway of the Obese Rat |
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| CHEN Chun-Ping , REN Hua , HE KE-shu , CHANG Bo.Effect of Exercise on LKB1 - AMPK - ACC Signal Pathway of the Obese Rat[J].Journal of Guangzhou Physical Education Institute,2012,32(4):101-104,113. | |
| Authors: | CHEN Chun-Ping REN Hua HE KE-shu CHANG Bo |
| Institution: | 1.Guang Dong Pei Zheng College,Guangzhou 510530,China; 2.Graduate Department,Shenyang Sport University,Shenyang 110102,China; 3.School of Human Sports Science,Shenyang 110102,China) |
| Abstract: | Obesity has become a danger to human health of the common chronic diseases,and exercise is recognized as one of the most effective ways in the treatment of obesity.AMPK(AMP-activated protein kinase) is an important metabolic stress protein kinases,the energy balance in the body plays the role of master switch.In the cells,AMPK can be activated by LKB1,and AMPK phosphorylation of ACC(acetyl coenzyme A carboxylase),reduces fatty acid synthesis and increases decomposition.In the condition of obesity,AMPK phosphorylation depressed,ACC activity enhanced,fatty acid synthesis increased,oxidation rate decreased.Exercise are important means of improving obesity,can enhance AMPK phosphorylation and decrease ACC activity.This article will explain the changing trends of LKB1-AMPK-ACC signaling pathway protein levels under the situation of obese state and the effect of exercise intervention on the protein content levels. |
| Keywords: | AMPK:ACC LKB1 obesity exercise |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |