| 力竭运动对小鼠心肌线粒体自由基代谢和线粒体功能的影响 |
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| 引用本文： | 王文成,刘克敏.力竭运动对小鼠心肌线粒体自由基代谢和线粒体功能的影响[J].广州体育学院学报,2008,28(1):106-107. |
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| 作者姓名： | 王文成 刘克敏 |
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| 作者单位： | 大连医科大学,运动医学教研室,辽宁大连,116027 |
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| 摘 要： | 探讨力竭运动对心肌线粒体功能的影响及与运动性疲劳的关系。把30只昆明种小鼠按体重随机分为3组，即安静对照组、力竭组及力竭后恢复24h组，以游泳为运动方式，观察各组心肌线粒体谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、总钙、丙二醛（MDA）和ATP合成能力的变化。通过与对照组相比，力竭运动组MDA含量很显著地升高（P〈0．05），SOD活性、GSH含量、总钙浓度和ATP合成能力均很显著地降低（P〈0．05），力竭运动后24h基本恢复。力竭运动可造成线粒体损伤和心肌损伤，力竭运动后24h各项指标基本恢复。
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| 关 键 词： | 力竭运动 心肌 线粒体 自由基 |
| 文章编号： | 1007-323X(2008)01-0106-02 |
| 修稿时间： | 2007年9月25日 |
Study on the Effect of Exhausting Exercise on Rat Metabolism of Mitochondrial Free Radicals and Mitochondrial Function |
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| WANG Wen-cheng,LIU Ke-min.Study on the Effect of Exhausting Exercise on Rat Metabolism of Mitochondrial Free Radicals and Mitochondrial Function[J].Journal of Guangzhou Physical Education Institute,2008,28(1):106-107. |
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| Authors: | WANG Wen-cheng LIU Ke-min |
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| Institution: | WANG Wen-cheng,LIU Ke-min(Department of Sports Medicine,Dalian University Medical,Dalian 116027,China) |
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| Abstract: | The objective of this paper is to study the changes of mitochondrial function in myocardiocytes after exhausting exercise in rat.Thirty mice were randomly divided into three groups of control,exhaustive swimming and 24 hours recovery after exhaustive swimming.The alterations of the three groups on the MDA content SOD activity GSH content Total calcium concentration and ATP activities were investigated.Compared with the controls,in exhaustive swimming group,the myocardial MDA were increased significantly(P<0... |
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| Keywords: | exhausting exercise myocardium mitochondrial free radicals |
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