| 力竭运动后大鼠大脑皮质结构与NGF、TrkA动态变化的研究 |
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| 引用本文： | 杨澎湃.力竭运动后大鼠大脑皮质结构与NGF、TrkA动态变化的研究[J].成都体育学院学报,2011,37(9). |
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| 作者姓名： | 杨澎湃 |
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| 作者单位： | 成都体育学院,四川 成都,610041 |
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| 摘 要： | 目的:探讨SD雄性大鼠在一次性力竭运动后,大脑皮质微结构和超微结构的形态改变与神经生长因子NGF、受体TrkA的动态变化关系.方法:随机将大鼠分为对照组(C组)、一次性力竭游泳运动后即刻组(E1)、12h组(E2)、24h组(E3)、48h组(E4),灌注定位取出大脑皮质,运用HE染色、铀铅双染,在光、电镜下观察大脑皮质结构变化,运用免疫组化技术检测大脑皮质中NGF和TrkA表达变化.结果:NGF、TrkA表达水平较C组显著性上升(P＜0.05)；E2组的NGF、TrkA的表达水平较E1组下调,其中TrkA的表达下调显著(P＜0.05)；NGF、TrkA的表达上升最为显著,较C组(P＜0.01)；E4组继续维持着高表达,较C组(P＜0.01).结论:一次性力竭运动后大脑皮质结构的损伤和重塑与NGF、TrkA动态表达具有一定的联系性.
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| 关 键 词： | 大脑皮质 力竭运动 NGF TrkA |
Structure and NGF, TrkA Dynamic Change in Rat Cerebral Cortex after Exhaustive Exercise |
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| YANG Peng-pai.Structure and NGF, TrkA Dynamic Change in Rat Cerebral Cortex after Exhaustive Exercise[J].Journal of Chengdu Physical Education Institute,2011,37(9). |
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| Authors: | YANG Peng-pai |
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| Institution: | YANG Peng-pai(Chengdu Sport University,Chengdu Sichuan China 610041) |
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| Abstract: | Objective: To investigate the dynamic relationship between the morphological changes of the micro-structure and ultrastructural of the cerebral cortex and nerve growth factor(NGF) and TrkA receptor in the SD male rats after one-time exhaustive exercise.Methods: After a model of one-time exhaustive swimming,rats are randomly divided into control group(C group) immediately after exercise group(E1),12h group(E2),24h group(E3),48h group(E4).The cerebral cortex is removed after perfusion and position.By using HE... |
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| Keywords: | cerebral cortex exhaustive exercise NGF TrkA |
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