| 肝脏脂质代谢与自噬 |
| |
| 作者姓名： | 黄莹 张芳 丁文军 |
| |
| 作者单位： | 中国科学院大学生命科学学院环境与健康实验室, 北京 100049 |
| |
| 基金项目： | 国家自然科学基金（11075207，20871120）、中国科学院科教融合项目（KJRH2015-003）和中国科学院知识创新工程重大项目（KSCX2-EW-J-29）资助 |
| |
| 摘 要： | 肥胖患者肝脏中过量的脂质堆积可引起肝细胞内质网应激、线粒体功能紊乱和脂毒性，该作用与胰岛素抵抗（IR）和非酒精性脂肪肝病（NALFLD）等代谢紊乱疾病的发生密切相关。自噬是细胞对内外持续性刺激的非损伤性应答反应，具有维持细胞结构和代谢平衡的功能。研究发现，自噬参与降解肝细胞内过多的脂质堆积，维持肝脏脂质代谢稳态。本文介绍了自噬调节肝脏脂质代谢的分子作用机制。
|
| 关 键 词： | 肥胖 肝脏 自噬 脂质代谢 |
| 收稿时间： | 2016-01-18 |
| 修稿时间： | 2016-03-08 |
Effect of autophagy on hepatic lipid metabolism in liver |
| |
| Authors: | HUANG Ying ZHANG Fang DING Wenjun |
| |
| Institution: | Laboratory of Environment and Health, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China |
| |
| Abstract: | It has been well demonstrated that lipid accumulation in liver of the obesity is involved in endoplasmic reticulum stress, mitochondria dysfunction, and lipotoxicity, which is associated with insulin resistance (IR) and nonalcoholic fatty liver disease (NAFLD).Autophagy has been considered to be an adaptive response to stress, contributing to cellular homeostasis.It has been found that autophagy is activated during hepatic lipid accumulation.Autophagy plays an essential role in maintaining hepatic lipid metabolism.This review summarizes recent studies to identify the molecular mechanism of autophagy maintaining hepatic lipid metabolism in the obesity. |
| |
| Keywords: | obesity liver autophagy lipid metabolism |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |
