| 8周跑台运动对肥胖大鼠下丘脑ghrelin和obestatin的影响 |
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| 引用本文： | 汪军,田吉明.8周跑台运动对肥胖大鼠下丘脑ghrelin和obestatin的影响[J].北京体育大学学报,2009(4). |
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| 作者姓名： | 汪军 田吉明 |
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| 作者单位： | 北京体育大学;山东大学体育学院; |
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| 基金项目： | 北京市重点实验室开放课题(2007TY021) |
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| 摘 要： | 目的:8周跑台运动对肥胖大鼠摄食以及血浆和下丘脑相关摄食内分泌指标的影响,初步探讨运动减肥的神经内分泌机制。方法:10周营养性肥胖建模SD大鼠分为对照组(LC)和运动组(LE)。大鼠专用跑台,坡度5%,速度20 m/min,运动时间40 min,进行8周运动后取材。每天观察LC组和LE组大鼠摄食量和体重;测试8周运动后肥胖大鼠血糖等基础指标;放射免疫方法测试血浆和下丘脑ghrelin和obestatin蛋白表达;RT-PCR方法测试下丘脑ghrelin受体GHSR-1a、obestatin假定受体GPR-39基因表达。结果:8周跑台运动后,两组大鼠体重都有增加,只是LE组增加的幅度较小;LE组大鼠摄食量显著下降,血糖等基础指标变化不明显;LE组大鼠血浆ghrelin和obestatin没有影响;下丘脑ghrelin和obestatin显著下降;GHSR-1a基因表达没有影响,而没有发现GPR-39基因表达。结论:Ghrelin可能通过中枢机制影响摄食和能量代谢调节;Obestatin-GPR39通路在能量代谢调节中可能不起作用。
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| 关 键 词： | 运动 减肥 摄食量 下丘脑 Ghrelin Obestatin |
Influence of 8-Week Treadmill Exercise on Hypothalamic Ghrelin and Obestatin of Obese Rats |
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| WANG Jun,TIAN Ji-ming.Influence of 8-Week Treadmill Exercise on Hypothalamic Ghrelin and Obestatin of Obese Rats[J].Journal of Beijing Sport University,2009(4). |
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| Authors: | WANG Jun TIAN Ji-ming |
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| Institution: | 1.Beijing Sport University;Beijing 100084;China;2.College of Physical Education;Shandong University;Jinan 250061;Shandong China |
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| Abstract: | This study aims to clarify the effects of 8-week treadmill exercise on levels of appetite regulatory hormones in plasma and hypothalamus of obese rats.Diet-induced obese rats undergo long-term(40 min,5 days/week for 8 weeks) exercises.The rats run at a speed of 20m/min-1 on a treadmill specialized for them.Rats undergoing long-term exercise(LE) are compared to long-term control(LC).The rats' meal size and body weight are researched every day.Concentrations of ghrelin and obestatin are measured by RIA.Expres... |
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| Keywords: | exercise weight losing appetite hypothalamus ghrelin obestatin |
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