| 有氧运动联合膳食干预对2糖尿病大鼠骨骼肌胰岛素受体亲和力的影响 |
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| 引用本文： | 刘霞,金其贯,叶鸣.有氧运动联合膳食干预对2糖尿病大鼠骨骼肌胰岛素受体亲和力的影响[J].北京体育大学学报,2010(2). |
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| 作者姓名： | 刘霞 金其贯 叶鸣 |
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| 作者单位： | 扬州大学体育学院;首都体育学院运动生理生化教研室; |
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| 摘 要： | 目的:研究有氧运动和膳食控制对2型糖尿病大鼠骨骼肌胰岛素受体亲和力的影响。方法:62只雄性大鼠,随机分为正常对照组(C组),DM对照组(DM)、DM+运动锻炼组(DME)、DM+膳食控制组(DMD)、DM+运动锻炼+膳食控制组(DMED),用受体放射性配基结合分析法(RBA)测定各组大鼠骨骼肌胰岛素受体亲和力。结果表明:1)与正常大鼠比较,糖尿病大鼠骨骼肌胰岛素高、低亲和力受体亲和力常数KD1、KD2都有非常显著性增加(P<0.01),受体结合容量RT1也有非常显著性增加(P<0.001),RT2显著性增加(P<0.05);2)与糖尿病对照组比较,糖尿病运动组KD1和RT2没有显著性变化(P>0.05),KD2有非常显著性下降(P<0.001),RT1有显著性下降(P<0.05);3)与糖尿病对照组比较,膳食控制组KD1、KD2、RT1和RT2都没有显著性变化(P>0.05),且运动和膳食控制没有交互作用(P>0.05)。结论:糖尿病大鼠胰岛素受体亲和力出现了显著性下降,有氧运动能够增强糖尿病大鼠胰岛素受体结合力,但膳食控制对其作用不明显,且与运动没有交互作用。说明胰岛素受体在糖尿病的发病机制及运动干预过程中...
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| 关 键 词： | 糖尿病 有氧运动 膳食控制 胰岛素受体 |
Effects of Aerobic Exercise and Dietary Control on the Affinity of Insulin Receptor of Skeletal Muscles in Diabetic Rats |
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| LIU Xia,JIN Qi-guan,YE Ming.Effects of Aerobic Exercise and Dietary Control on the Affinity of Insulin Receptor of Skeletal Muscles in Diabetic Rats[J].Journal of Beijing Sport University,2010(2). |
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| Authors: | LIU Xia JIN Qi-guan YE Ming |
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| Institution: | 1.Physical Education College;Yangzhou University;Yangzhou 225009;Jiangsu China;2.Department of sport physiology;Capital institute of physical education;Beijing 100088;China |
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| Abstract: | The objective of the thesis is to research the effects of aerobic exercise and dietary control on the affinity of insulin receptor of skeletal musclesof diabetic rats.Method:62 male SD rats were randomly divided into fived groups:control group(C),diabetes group(DM),diabetes and exercise group(DME),diabetes and dietary control group(DMD),diabetes and exercise and dietary control group(DMED),We measured the affinity of insulin receptor of skeletal muscles in all rats by RBA.Result:1)Compared with the controll... |
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| Keywords: | diabetes aerobic exercise dietary control insulin receptor |
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